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Metabolism Diazepam is N-demethylated by CYP3A4 and 2C19 towards the Energetic metabolite N-desmethyldiazepam, and it is hydroxylated by CYP3A4 on the active metabolite temazepam.A medication that requires a prescription and is also used as a short-time period treatment for insomnia which include getting difficulties sleeping, nocturnal awakening,